PRP vs. PRF Similarities and Differences

by in PRP (Platelet Rich Plasma) August 26, 2022

PRP and PRF are both popular treatments. These treatments are used for similar cosmetic procedures. And the efficacy is impossible to deny. So, what are the difference between PRP vs PRF? Which one is best for you? Let’s find out.

At A Glance

Essentially, PRF and PRP are similar in application, but differ in their effects. Indeed, PRP dominated the market for a while. It was the only viable platelet-based therapy for regeneration. However, in recent years, Platelet Rich Fibrin has shown to be more effective.


Platelet rich fibrin is prepared by extracting blood from the patient. Then, the blood goes into a centrifuge to separate the platelets from the rest of the blood. The provider injects this processed product into the skin. PRF shows great potential for rejuvenating the skin, restoring hair growth, and improving skin texture. Furthermore, it is an effective way to prevent deep facial hollows and fine lines.


On the other hand, Platelet rich plasma also uses the regenerative factors present in the patient’s blood. It aids in exfoliation and improving the skin’s appearance. Additionally, PRP injections may speed up the healing process of injured tendons, ligaments, muscles, and joints.

Similarities of PRP vs PRF PRP vs PRF

The two treatments are similar in several ways, including:

  1. Rich in special proteins and growth factors
  2. Autologous platelet concentrates
  3. Potential solutions to aesthetic issues like acne scarring, aged skin, and dark spots
  4. Novel, platelet-based procedures
  5. All-natural treatment option

Differences in PRP vs PRF

While these are both platelet based regenerative treatments, they differ in technical aspects, as well as potency of platelets.

During PRF, the centrifuge spins slower, allowing it to extract more platelets. Also, since its gentler, it causes less damage to the cells. PRF is rich in healing factors like white blood cells, stem cells, and fibrin. It also has a higher potency of platelets.

Finally, the fibrin concentration causes the PRF solution to be in the forb of a matrix or scaffold. This means the platelets have a support structure. They remain in the area much longer, therefore producing better results.

On the other hand, PRP is collected at a high speed. Therefore, it has a lower number of platelets and lacks the heavier components like white blood cells, stems cells and fibrin. Lastly, the PRP process involves anticoagulants. Combined with the lack of fibrin, PRP lacks a support structure. So, it releases the platelets and growth factors at a much faster rate.

PRP vs PRF Near Me

Undoubtedly both treatments are good options for many people. To learn more about which might be best for you, please contact Reston Dermatology and Cosmetic Center.

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